Matt Dominguez was born in Georgetown, Texas. He grew up in Georgetown, the oldest of six children. Matt received a football scholarship after high school to attend Sam Houston State University. At Sam Houston State he was the school’s first NCAA Div I-AA All-American, Matt caught 211 passes for 3,272 yards and 27 touchdowns. In 1998 and 1999, he was the teams MVP and still holds eight Sam Houston State records and five Southland Football League records. In 2005, Matt was inducted into the Sam Houston Hall of Fame.
After University Matt was originally signed as an undrafted free agent by the Denver Broncos, he spent 2001 on the active roster and was sidelined in 2002 with his first knee injury.
After being released Dominguez was signed by the Roughriders in 2003 and quickly used his size to his advantage and became a fan favourite by gaining over 1,000 yards in his first year.
In 2004 Dominguez signed with the New York Jets of the National Football League. He was cut at the end of training camp.
He returned to Regina and the Roughriders after being released. In total he played five years with the Green and White becoming a top notch CFL receiver. In 2006, Matt was named a West Division All-Star and in 2007 he was part of the Grey Cup Championship Team. Dominguez was eventually released by the Roughriders on February 13, 2009.
Dominguez along with his then teammate Gene Makowsky made a cameo appearance in the Corner Gas episode “Reader Pride”.